The Experts Have Done Their Homework.
Ketamine has been around for decades, but scientists’ understanding of it is constantly evolving. With one revelation after another, the medical community is discovering that this anesthetic is more useful for promoting wellbeing than they had anticipated. More than a few research teams have tested ketamine’s meddle, and more than a few tests have met with favorable results.
Dr. Carlos Zarate, Principal Investigator at the National Institute of Mental Health (NIHM), set out to find an antidepressant without a weeks-long delay in results. He and colleagues treated one group of patients with ketamine, treated another group with a placebo, and gauged their moods on the Hamilton Depression Rating Scale. Patients with ketamine infusions showed improvement over the placebo patients—within two hours! For over one-third of them, that improvement lasted for a full week. Zarate’s study set the stage for further findings.
Ketamine was able to put plain depression in its place, but how well does it stand up against bipolar depression? Dr. Nancy Diazgranados and company launched an investigation to answer that question. Their team saw depression relief in under an hour! NIHM had just met the next generation of psychiatric medicine.
Researchers have also pitted ketamine against obsessive compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). For the OCD study, PubMed scientists selected patients who spent at least half of their waking hours struggling with intrusive thoughts at the time. They witnessed a rapid breakdown of obsessions among the most severe cases. The PTSD study found ketamine to be a superior alternative to midazolam for symptom reduction. Doctors call it an N-methyl-D-aspartate antagonist; people who have benefitted from the medicine call it life-changing.
Ketamine has also been causing buzz in the mainstream. See what some major news outlets have to say!
- John Hamilton of NPR: “[K]etamine works by encouraging synaptic connections.”
- ECaroline Winter from Bloomberg Businessweek: “Additional studies show that ketamine works by producing long-lasting changes in the brain, reversing neural damage caused by stress and depression and potentially decreasing inflammation and cortisol levels.”
- Sara Solovitch of The Washington Post: “Since 2006, dozens of studies have reported that it can also reverse the kind of severe depression that traditional antidepressants often don’t touch.”
Ketamine’s unique successes have inspired a wave of imitators. As the pharmaceutical industry scrambles to develop copycat medications—and then profit from them—don’t forget the breakthrough remedy that launched the trend. Medical experts across multiple fields see promise in its ability to put the nervous system back on track.
The test scores are in. When it comes to supporting mental health, ketamine makes the grade. Now residents of the Springs can access its high-achieving potency through Colorado Infusion Solutions. Our modern ketamine infusion procedures are built upon previous generations of research. We are pleased to offer one of the most promising cures in contemporary medicine. More importantly, we are pleased to help alleviate chronic pain in the Colorado Springs area. Contact Colorado Infusion Solutions today. We would love to be a part of your journey toward wellness.
Ketamine for Depression
- “Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior” by Biological Psychiatry Journal, May 1, 2016
- “Effects of ketamine on cognition–emotion interaction in the brain” by NeuroImage, January 1, 2016
- “Rapid Agent Restores Pleasure-seeking Ahead of Other Antidepressant Action” by National Institute of Mental Health, October 17, 2014
- “Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder” by JAMA Psychiatry, June 2014
Ketamine for Pain
- “Ten Year Review of Intravenous Ketamine in the Treatment of Cancer-Related Pain (FR420B)” by PAIN – The Journal of the International Association for the Study of Pain, February 2017
- “Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series” by Journal of Headache Pain, November 22, 2016
- “NMDAR inhibition-independent antidepressant actions of ketamine metabolites” by Nature, May 26, 2016
- “The Role of a Low-Dose Ketamine-Midazolam Regimen in the Management of Severe Painful Crisis in Patients With Sickle Cell Disease” by PAIN – The Journal of the International Association for the Study of Pain by February 2014
- “Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study” by BMC Pediatrics, March 26, 2015
- “Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study.” by PubMed US National Library of MedicineNational Institutes of Health, December 15, 2009
WHAT IS KETAMINE?
Ketamine is a medicine developed more than 50 years ago for anesthesia during surgery, and has been used for that purpose since that time in children, adults, and animals. More recently, ketamine has been found to be a valuable and highly effective treatment for depression, anxiety, and certain pain disorders.
IS THERE POTENTIAL FOR ADDICTION?
Some may have heard that ketamine is used as a “party drug” and worry about addiction potential. Studies and clinical experience have found that in the very low doses used, medical setting, lack of access at home, and infrequent dosing, there is virtually no potential for addiction or abuse.
WHAT ARE THE RISKS?
The dose used for the treatment of mood and anxiety disorders is very low and safe. For a few minutes during the infusion itself, blood pressure and heart rate may increase. This is monitored to ensure safety.
WHAT IS IT LIKE TO HAVE A KETAMINE INFUSION?
The medicine is given very slowly over 40 minutes. The first 15-20 minutes are uneventful with no noticeable effects. At around the 20 minute point, people tend to notice some blurring of vision or double vision, a feeling of “lightness”, “floating”, or intoxication, and sometimes some numbness in the toes or area around the mouth. Over the course of this 20 minute period, these feelings tend to build, so that the medicine is at the peak of its intensity at the very end. Other common feelings include euphoria, talkativeness, a feeling of being “disconnected” or in a dream, heightened perceptions (background noise may seem louder, colors or lights are more intense), and a feeling that people often describe as “weird, odd, different, or interesting”.
Less commonly, people may experience some anxiety and headache, nausea, or sweating (typically toward the end). These feelings start to subside approximately 10-15 minutes after the medicine is done and last for a total of 45-50 minutes. Most people can expect to be with us for about 90 minutes from the time you walk in the door to when you leave, with no side effects at that point and none between treatments.
WHAT SHOULD I DO DURING THE INFUSION?
Many find it helpful and relaxing to listen to music and to wear an eyeshade or sunglasses. It can be difficult to carry on a conversation during the procedure, so you are encouraged to sit back and relax and pay attention to what you are feeling. Expectations coming in to the treatment do affect the experience, so it is helpful to decide ahead of time that you will be safe, will feel “weird” for a little while, and that is ok, because that will quickly pass and you will be left feeling much better.